I'm finding the controls excellent (I don't do much gaming so I'm not getting any cofusion with other games and their layouts) but the weirdest bit is using the Nunchuk to throw your grenades, as it says that you have to flick it to throw one. Also it feels a lot easier to move around than from what I remember from the PS2 when I last played that version.
The aiming is spot on and flicking from weapon to weapon is easy.
I shall be having a large session on it later today just to really get used to the controls (as with all real men I never looked at the instructions but waded straight into the gameplay until I couldn't do certain things and then had a look) but from my initial couple of hours play I am very impressed with what Rebellion have done to make it Wii compatible.
One last thing, after watching the cinematic start to the game again, it really makes you want to see cartoon versions of the House of Tharg's characters but alas one can only dream!