The 'human brain' Blackbloods idea is a great one on Pat's part. It ties together many strings from Savage, Ro-Busters and ABC Warriors. Howard Quartz, who is a Bill Gates/Richard Branson/Donald Trump(?) amalgam in his Savage incarnation, will famously go on to be a brain in a robot body as Mr. 10% in Ro-Busters, so the technology cannot be far off (at least before he dies of old age). Hammerstein himself, as a Mark III, is also the first robot to be built with emotions (according to the gorgeous SMS-drawn flashback episode in the Black Hole story), intended as a solution to the friend-or-foe problems with the Mark I's and II's.
This suggests that true artificial intelligence is still pretty basic when (prior to?) Old Red Eyes is being constructed sometime in the middish 21st century, but that organic-brain-to-machine interface technology is better understood, at least from 2010 on.
As long as our Blackblood doesn't turn out to still have an organic brain (which would invalidate his whole Church of Judas schtick), I'll be very pleased with this turn of events.